陳利民—研究員

 

                                                                         

      陳利民，1967年2月出生， 瀘州醫學院（西南醫科大學）本科、華西醫科大學（四川大學）碩士，多倫多大學博士，研究員，“協和學者”特聘教授，博士生導師。哈佛大學博士后研究員。入選“四川省衛健委學術和技術帶頭人”、“四川省衛健委領軍人才”等稱號?，F任醫科院輸血所輸血傳播疾病平臺主任。四川省輸血傳播疾病醫學重點實驗室主任，國家重點研發計劃首席科學家。主要從事輸血傳播疾病的基礎及轉化研究、輸血傳播病原體的診斷、滅活及耐藥機制研究等，有關輸血傳播病毒致病及耐藥機制、個體化精準治療策略等相關研究結果已在多種國際雜志上發表SCI論文80多篇，引用1500余次。
 
研究方向
       輸血傳播疾病基礎及轉化研究，輸血傳播病原體診斷及滅活技術研究，輸血（蚊媒）傳播病原體與輸血安全
 
社會任職及榮譽
       中國輸血協會輸血傳播疾病專業委員會副主任委員，中國輸血協會血液安全監測專業委員會委員，重慶市中西醫結合學會肝病專委會常務委員，四川省輸血協會專家委員會委員；四川省醫學會第一屆轉化醫學專委會委員，中國醫學科學院首屆青年科學家聯盟理事；中國醫學科學院、北京協和醫學院第六、七屆學術委員會委員；中國自然科學基金委重點項目特邀評審專家，多個國家重點研發計劃、科技重大專項評審專家；國家衛健委重點實驗室評審及驗收專家。Journal of Clinical and Translational Hepatology 副主編，Journal of Infectious Diseases、《中國輸血雜志》及《腫瘤預防與治療》等雜志編委。研究成果獲得2013年亞太肝病年會（新加坡）大會主席獎（Presidential Award）及2015年四川省醫學科技（青年）一等獎
 
承擔科研項目情況

1. 國家重點研發計劃政府間國際科技合作重點專項“輸血傳播病毒性肝炎轉化醫學及精準治療策略研究”（2018YFE0107500）  2019.8-2023.7
2. 國家自然科學基金面上項目，“泛素化特異性蛋白酶USP18在丙肝病毒耐受干擾素中的作用及分子機制研究“（81471956）   2015.1-2018.12
3. 國家自然科學基金重大研究計劃培育項目“肝臟炎性微環境通過ISG15/USP18影響巨噬細胞分化及肝細胞先天免疫導致丙肝病毒耐藥的機制研究”（91442128） 2015.1-2017.12
4. 國家自然科學基金委員會（中德科學基金研究交流中心）新型冠狀病毒中德合作研究應急專項項目 “預防新冠病毒肺炎感染的新方法：經過功能修飾的微小蛋白顆粒噴霧劑”（C-0029）2020.10-2021.9
5. 科技部對發展中國家常規援外項目“老撾獻血人群新發再發病原體篩查體系的建立及應用”（KY201904011） 2020.1-2022.12
6. 國家外專局“病毒學肝炎個體化治療關鍵技術研究”（WZ20150623）  2015.1-2016.12
7. 人社部留學回國人員科技活動項目擇優資助 “病毒性肝炎耐藥機理及干擾素治療丙肝療效預測方法的建立” 2012.9-2013.9
8. 四川省委組織部 “病毒性肝炎個體化治療及轉換醫學” 2011.5-2016.12
9. 四川省科技廳國際合作項目“基于基因組學的乙肝病毒耐藥新機制：ISG15/USP18信號通路在HBV耐藥中的作用” (2017HH0024) 2017.1-2018.12
10. 四川省科技廳國際合作項目“病毒性肝炎個體化治療療效預測方法的建立”   （2013HH0013）2013.1-2014.12
11. 四川省科技廳科技支撐計劃 “預測干擾素治療丙型肝炎療效的方法” （2011SZ0010）   2011.01-2013.12

　　……..
代表論著
       著作
       主編專著一部，參編專著五部

1. Hepatitis C Virus Infection: predicting treatment response and the molecular mechanism of interferon resistance (主編）
2. Hepatitis C Virus: Molecular Pathways and Treatments (參編）
3. Microarrays: Principles,Applications and Technologies (參編）
4. The Battle Against Microbial Pathogens: Basic Science, Technological Advances and Educational Programs (參編）
5. Microbial Pathogens and Strategies for Combating them: Science, Technology and Education（參編）
6. 中華輸血學第二版（參編）

　
　　代表性論文

1. Haiyan Ye, Lan Kang, Xipeng Yan , Shilin Li , Yike Huang , Rongrong Mu , Xiaoqiong Duan and Limin Chen.MiR-103a-3p Promotes Zika Virus Replication by Targeting OTU Deubiquitinase 4 to Activate p38 Mitogen-Activated Protein Kinase Signaling Pathway.Front. Microbiol. 2022;13:862580. doi: 10.3389/fmicb.2022.862580
2. Shuang Li and Limin Chen. Exosomes in Pathogenesis, Diagnosis, and Treatment of Hepatocellular Carcinoma.Front. Oncol.2022;12:793432. doi:10.3389/fonc.2022.793432
3. Xianlin Ye , Yu Zhao , Ran Li , Tong Li , Xin Zheng , Wen Xiong , Jinfeng Zeng, Min Xu and Limin Chen. High Frequency Occult Hepatitis B Virus Infection Detected in NonResolved Donations Suggests the Requirement of Anti-HBc Test in Blood Donors in Southern China.  Frontiers in Immunology2021,12:699217. doi: 10.3389/fimmu.2021.699217
4. Haiyan Ye, Xiaoqiong Duan, Min Yao, Lan Kang, Yujia Li, Shilin Li*, Bin Li*, Limin Chen*.  USP18 mediates interferon resistance of dengue virus infection . Frontiers in Microbiology 2021 12:682380. doi: 10.3389/fmicb.2021.682380
5. He Xie, Honggang Sun, Rongrong Mu, Shilin Li, Yujia Li, Chunhui Yang, Min Xu, Xiaoqiong Duan*, and Limin Chen*. The role of circular RNAs in viral infection and related diseases. Virus Research 2021;291:198205
6. Xianlin Ye, Tong Li, Ruohao Zhang, Heng Liu, Jinfeng Zeng, Wenxu Hong, Liang Lu, Weigang Zhu, Shilin Li, Min Xu , Shaobo Wu, and Limin Chen.Comprehensive analysis of hepatitis B virus infections in blood donors in southern China that are surface antigen positive but nucleic acid testing negative. Transfusion2020;50:1476-1482
7. Xiao Liu,* Xiaoqiong Duan,* Jacinta A. Holmes,Wenting Li, Sae Hwan Lee,Zeng Tu, Chuanlong Zhu,Shadi Salloum,Anna Lidofsky,Esperance A. Schaefer,Dachuan Cai, Shilin Li,Haoju Wang,Yongfu Huang,Yongju Zhao,Ming-Lung Yu, Zhiwen Xu,Limin Chen,Jian Hong,Wenyu Lin, and Raymond T. Chung. A Long Noncoding RNA Regulates Hepatitis C Virus Infection Through Interferon Alpha–Inducible Protein 6.Hepatology 2019;69(3):1004-1019
8. Xiaoqiong Duan , Xiao Liu, Wenting Li , Jacinta A. Holmes, Annie J. Kruger, Chunhui Yang,Yujia Li,Min Xu,Haiyan Ye,Shuang Li,Xinzhong Liao,Qiuju Sheng ,Dong Chen,Tuo Shao,Zhimeng Cheng,Batul Kaj,Esperance A. Schaefer, Shilin Li,Limin Chen*,Wenyu Lin *, and Raymond T. Chung. Microrna-130a Downregulates HCV Replication through an atg5-Dependent Autophagy Pathway. Cells2019;8:338 doi:10.3390/cells8040338 
9. Li Y, Ma MX, Qin B, Lin LT, Richardson CD, Feld J, McGilvray ID, Chen L.The Ubiquitin-Specific Protease 18 Promotes Hepatitis C Virus Production by Increasing Viral Infectivity. Mediators of Inflammation2019 Nov 18;2019:3124745. doi: 10.1155/2019/3124745. eCollection 2019.
10. Duan X, Li S, Holmes JA, Tu Z, Li Y, Cai D, Liu X, Li W, Yang C, Jiao B, Schaefer EA, Fusco DN, Salloum S, Chen L*, Lin W, Chung RT*. MicroRNA 130a Regulates both Hepatitis C Virus and Hepatitis B Virus Replication through a Central Metabolic Pathway.J Virol.2018 Mar 14;92(7). pii: e02009-17
11. Xiaoqiong Duan, Yujuan Guan, Yujia Li, Shan Chen, Shilin Li, and Limin Chen*. Vitamin D Potentiates the Inhibitory Effect of MicroRNA-130a in Hepatitis C Virus Replication Independent of Type I Interferon Signaling Pathway. Mediators of InflammationVolume 2015, Article ID 508989http://dx.doi.org/10.1155/2015/508989
12. S. Li, X. Duan, Y. Li, B. Liu, I. McGilvrayand L. Chen*. MicroRNA-130a inhibits HCV replication by restoring the innate immune response. Journal of Viral hepatitis2014;21(2):121-8
13. Limin Chen, Ivan Borozan, Maha Guindi,Jing Sun, Nitasha Anand, Jenny Heathcote, Aled M. Edwards, Ian D. McGilvray.  Cell-type specific gene expression signature in liver underlies response to interferon therapy in chronic hepatitis C infection.Gastroenterology2010;138(3):1123-1133.e3.
14. Limin Chen, Jing Sun, larry Meng, Jenny Healthcote, Aled Edwards, Ian McGilvray. ISG15, a ubiquitin-like interferon-stimulated gene, promotes hepatitis C virus production in vitro:Implications for chronic infection and response to treatment.   Journal of General Virology2010 Feb;91(Pt 2):382-8.
15. Randall G, Chen L, Panis M, Fischer AK, Lindenbach B, Sun J, Heathcote J, Rice  CM, Edwards AM, McGilvray ID. Silencing of USP18 potentiates the antiviral activity of interferon against hepatitis C virus infection.  Gastroenterology 2006; 131(5):1584-91
16. Ivan Borozan*, Limin Chen*,  Jing Sun, Laura-Lee Tannis, Maha Guindi, Ori D. Rotstein, Jenny Heathcote, Aled M. Edwards, David Grant,Ian D. McGilvray^.  Gene expression profiling of acute liver stress during living donor liver transplantation   American Journal of Transplantation  2006 Apr;6(4):806-24  
17. Chen L., Ivan Borozan, Jordan Feld, Jing Sun, Laura-Lee Tannis, Catalina Coltescu, Jenny Heathcot, Aled M. Edwards, Ian D. McGilvray.  Hepatic gene expression profiling discriminates responders and non-responders in treatment of chronic hepatitis C viral infection . Gastroenterology 2005; 128:1437-1444
18. Chen L, Goryachev A, Sun J, Kim P, Zhang H, Phillips MJ, Macgregor P, Lebel S, Edwards AM, Cao Q, Furuya KN. Altered expression of genes involved in hepatic morphogenesis and fibrogenesis are identified by cDNA microarray analysis in biliary atresia. Hepatology. 2003 Sep;38(3):567-76

 
聯系方式
電話：028-61648530；13086636245 
E-mail: limin.chen@ibt.pumc.edu.cn   limin_chen_99@126.com